Alexa Fluor® 750 Anti-G3BP antibody [EPR13985(B)],Abcam,AB321248
Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . How are conjugated primary antibodies validated? This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling. For suitable applications and species reactivity, please refer to the unconjugated version of this clone. Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].
Host
Rabbit
Reactivity
Human
Application
Flow Cyt, Antibody Labelling, IHC-P, ICC/IF, Target Binding Affinity
Conjugate
Alexa Fluor® 750
Platform ID
BAB132869279
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Protein involved in various processes, such as stress granule formation and innate immunity (PubMed : 12642610, PubMed : 20180778, PubMed : 23279204, PubMed : 30510222, PubMed : 30804210). Plays an essential role in stress granule formation (PubMed : 12642610, PubMed : 20180778, PubMed : 23279204, PubMed : 32302570, PubMed : 32302571, PubMed : 32302572, PubMed : 34739333, PubMed : 35977029, PubMed : 36183834, PubMed : 36279435, PubMed : 36692217, PubMed : 37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed : 12642610, PubMed : 20180778, PubMed : 23279204, PubMed : 27022092, PubMed : 32302570, PubMed : 32302571, PubMed : 32302572, PubMed : 36279435, PubMed : 37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding : functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed : 32302570, PubMed : 32302571, PubMed : 32302572, PubMed : 34739333, PubMed : 36279435, PubMed : 36692217). Also acts as an ATP- and magnesium-dependent helicase : unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed : 9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed : 9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed : 9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed : 30510222, PubMed : 30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed : 30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed : 34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed : 30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro : Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed : 11604510). See full target information G3BP1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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