Anti-5HT1A Receptor antibody,Abcam,AB227165

Target data G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 37935376, PubMed : 37935377, PubMed : 8138923, PubMed : 8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 38552625, PubMed : 8138923, PubMed : 8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 22957663, PubMed : 3138543, PubMed : 33762731, PubMed : 8138923, PubMed : 8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission : signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed : 33762731, PubMed : 35610220). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). Plays a role in the response to anxiogenic stimuli (PubMed : 18476671, PubMed : 20363322, PubMed : 20945968). See full target information HTR1A