Anti-5HT1B Receptor antibody,Abcam,AB52025

Target data G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 10452531, PubMed : 1315531, PubMed : 1328844, PubMed : 1348246, PubMed : 1351684, PubMed : 1559993, PubMed : 1565658, PubMed : 1610347, PubMed : 23519210, PubMed : 23519215, PubMed : 29925951, PubMed : 8218242). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (PubMed : 23519210, PubMed : 23519215, PubMed : 29925951). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 10452531, PubMed : 1315531, PubMed : 1328844, PubMed : 1348246, PubMed : 1351684, PubMed : 1559993, PubMed : 1565658, PubMed : 1610347, PubMed : 23519210, PubMed : 23519215, PubMed : 29925951, PubMed : 8218242). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed : 29925951, PubMed : 35610220). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed : 29925951). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (PubMed : 18476671, PubMed : 20945968). Besides, plays a role in vasoconstriction of cerebral arteries (PubMed : 15853772). See full target information HTR1B