Anti-5HT1D Receptor antibody,Abcam,AB140486

Target data G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 10452531, PubMed : 1565658, PubMed : 1652050, PubMed : 33762731). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed : 10452531, PubMed : 1565658, PubMed : 1652050, PubMed : 33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 10452531, PubMed : 1565658, PubMed : 1652050, PubMed : 33762731). HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed : 33762731). Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (PubMed : 18476671, PubMed : 20945968). May also play a role in regulating the release of other neurotransmitters (PubMed : 18476671, PubMed : 20945968). May play a role in vasoconstriction (PubMed : 18476671, PubMed : 20945968). See full target information HTR1D