Anti-5HT1F Receptor antibody,Abcam,AB230778

Host

Rabbit

Reactivity

Human

Application

IHC-P

Platform ID

BAB766988664

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-5HT1F Receptor antibody
Cat. No.AB230778
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human HTR1F. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.099% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 21422162, PubMed : 34239069, PubMed : 8380639, PubMed : 8384716). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed : 21422162, PubMed : 8380639, PubMed : 8384716). Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed : 34239069). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 34239069). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed : 34239069, PubMed : 35610220). See full target information HTR1F

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