Anti-5HT2A Receptor antibody,Abcam,AB216959

Target data G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 1330647, PubMed : 18703043, PubMed : 19057895, PubMed : 21645528, PubMed : 22300836, PubMed : 35084960, PubMed : 38552625). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed : 28129538, PubMed : 35084960). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed : 28129538, PubMed : 35084960). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed : 18703043, PubMed : 28129538, PubMed : 35084960). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed : 28129538, PubMed : 35084960). Affects neural activity, perception, cognition and mood (PubMed : 18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. See full target information HTR2A