Anti-ABCB6/PRP antibody [EPR21891],Abcam,AB221159

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human

Application

Flow Cyt (Intra), ICC/IF

Platform ID

BAB143275546

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-ABCB6/PRP antibody [EPR21891]
Cat. No.AB221159
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationFlow Cyt (Intra), ICC/IF
ClonalityMonoclonal
Clone NumberEPR21891
Concentration0.558 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed : 17661442, PubMed : 23792964, PubMed : 27507172, PubMed : 33007128). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed : 10837493, PubMed : 17006453, PubMed : 23792964, PubMed : 33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed : 29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed : 21266531, PubMed : 25202056, PubMed : 31053883). In addition may play a role in the transition metal homeostasis (By similarity). See full target information ABCB6

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