Anti-ABCG8 antibody,Abcam,AB126493

Host

Rabbit

Reactivity

Human

Application

ICC/IF, WB, IHC-P

Platform ID

BAB893450462

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-ABCG8 antibody
Cat. No.AB126493
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF, WB, IHC-P
ClonalityPolyclonal
Concentration0.3 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human ATP-binding cassette sub-family G member 8 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed : 11099417, PubMed : 11452359, PubMed : 15054092, PubMed : 27144356). Required for normal sterol homeostasis (PubMed : 11099417, PubMed : 11452359, PubMed : 15054092). The heterodimer with ABCG5 has ATPase activity (PubMed : 16893193, PubMed : 20210363, PubMed : 27144356). See full target information ATP-binding cassette sub-family G member 8

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