Anti-AGTR1 antibody [HL2526] - BSA and Azide free,Abcam,AB325838

Target data Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed : 15611106, PubMed : 1567413, PubMed : 25913193, PubMed : 26420482, PubMed : 30639100, PubMed : 32079768, PubMed : 8987975). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed : 15611106).. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. See full target information AGTR1