Anti-AICDA antibody - Aminoterminal end,Abcam,AB137397

Host

Rabbit

Reactivity

Human

Application

WB, ICC/IF, IHC-P

Platform ID

BAB585542007

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-AICDA antibody - Aminoterminal end
Cat. No.AB137397
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, ICC/IF, IHC-P
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human AICDA aa 1-100. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed : 18722174, PubMed : 21385873, PubMed : 21518874, PubMed : 27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed : 21496894). See full target information AICDA

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