Anti-AKT1 (phospho T342) antibody,Abcam,AB228808

Target data Serine/threonine kinase involved in various developmental processes (PubMed : 10587646, PubMed : 10962553, PubMed : 11740943, PubMed : 11872800, PubMed : 12172554, PubMed : 12893776, PubMed : 14525946, PubMed : 15466161, PubMed : 15712201, PubMed : 9601646). During early embryogenesis, acts as a survival protein (PubMed : 10962553, PubMed : 9601646). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination (PubMed : 11740943). Also regulates tracheal cell migration (PubMed : 11740943, PubMed : 14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed : 10587646, PubMed : 10962553, PubMed : 11752451, PubMed : 12893776, PubMed : 24603715, PubMed : 25329475, PubMed : 29025897). Controls follicle cell size during oogenesis (PubMed : 15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex (PubMed : 12172554, PubMed : 15466161). Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth (PubMed : 10962553). See full target information Akt phospho T342