Anti-ALDH1A1 antibody [EP1933Y] - C-terminal,Abcam,AB52492
What is this antibody validated in? Anti-ALDH1A1 antibody [EP1933Y] - C-terminal (ab52492) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. What is the molecular weight of ALDH1A1? Anti-ALDH1A1 [EP1933Y] - C-terminal (ab52492) specifically detects a band for ALDH1A1 (UniProt: P00352) at a molecular weight of 55kDa. Trusted by the scientific community Anti-ALDH1A1 [EP1933Y] - C-terminal (ab52492) was first used in a scientific publication in 2007 and has been cited over 180 times in peer-reviewed journals. Reviewed by scientists Anti-ALDH1A1 [EP1933Y] - C-terminal (ab52492) has over 20 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-ALDH1A1 antibody [EP1933Y] - C-terminal (ab52492) has been confirmed by Western blot testing in ALDH1A1 Knockout A549 cells. Other related products We have a range of other formats of antibody clone [EP1933Y] also available for your convenience: ab52492, Alexa Fluor® 488 - ab195254 , Alexa Fluor® 647 - ab195255 , HRP - ab195517 , Alexa Fluor® 594 - ab206884 , PE - ab209437 , Carrier free - ab215996 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Species reactivity Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
Host
Rabbit
Reactivity
Mouse, Human
Application
WB, IHC-P, Flow Cyt (Intra), IP, ICC/IF
Platform ID
BAB462178721
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed : 12941160, PubMed : 15623782, PubMed : 17175089, PubMed : 19296407, PubMed : 25450233, PubMed : 26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed : 12941160, PubMed : 15623782, PubMed : 19296407). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed : 17175089). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). See full target information ALDH1A1
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- Products>Primary Antibodies>Monoclonal Antibodies
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