Anti-ALKBH3 antibody,Abcam,AB227496

Target data Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed : 12486230, PubMed : 12594517, PubMed : 16174769, PubMed : 26863196, PubMed : 26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed : 12486230, PubMed : 12594517, PubMed : 16174769, PubMed : 25944111). Has a strong preference for single-stranded DNA (PubMed : 12486230, PubMed : 12594517, PubMed : 16174769, PubMed : 20714506). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed : 22055184). Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA (PubMed : 25797601). Also acts on RNA (PubMed : 12594517, PubMed : 16174769, PubMed : 16858410, PubMed : 26863196, PubMed : 26863410). Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed : 26863196, PubMed : 26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed : 16858410, PubMed : 22055184). See full target information ALKBH3