Anti-AMID antibody [EPR29828-39] - BSA and Azide free,Abcam,AB326077
ab326077 is the carrier-free version of ab324520 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Human
Application
WB, ICC/IF
Platform ID
BAB014203737
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (PubMed : 31634899, PubMed : 31634900, PubMed : 35922516, PubMed : 36788244, PubMed : 37957306, PubMed : 39881208, PubMed : 37739993, PubMed : 39160155, PubMed : 38414669, PubMed : 40233740). At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis (PubMed : 31634899, PubMed : 31634900, PubMed : 37739993, PubMed : 39160155, PubMed : 38414669, PubMed : 40233740). Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis (PubMed : 31634899, PubMed : 31634900). This anti-ferroptotic function is independent of cellular glutathione levels (PubMed : 31634899, PubMed : 31634900). Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle : catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms (PubMed : 35922516, PubMed : 36788244). Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis (PubMed : 35922516). May play a role in mitochondrial stress signaling (PubMed : 26689472). Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed : 26689472). Capable of DNA binding in a non-sequence specific way (PubMed : 15958387). See full target information AIFM2
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