Anti-ARPC5/p16 ARC antibody [EP1551Y],Abcam,AB51243

Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P, IP, WB in human, mouse, rat samples. Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) has been cited over 158 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) has been confirmed by testing in knockout samples. Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) has 5 independent reviews from customers. Anti-ARPC5/p16 ARC antibody [EP1551Y] (ab51243) specifically detects ARPC5/p16 ARC (UniProt ID: O15511; Molecular weight: 16kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EP1551Y - ab220800 . Antibody clone EP1551Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 594, PE, APC, Alexa Fluor® 750 ( ab320122 , ab320123 , ab320124 , ab320125 , ab320126 , ab320127 , ab321644 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

IHC-P, ICC/IF, IP, WB

Platform ID

BAB778471885

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-ARPC5/p16 ARC antibody [EP1551Y]
Cat. No.AB51243
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationIHC-P, ICC/IF, IP, WB
ClonalityMonoclonal
Clone NumberEP1551Y
Concentration0.172 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed : 9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed : 9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed : 29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed : 29925947). See full target information ARPC5

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