Anti-ARRDC1 antibody,Abcam,AB181758

Target data Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed : 23886940, PubMed : 27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed : 27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed : 22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed : 23886940). See full target information Arrestin domain-containing protein 1