Anti-ATF6 antibody [1-7],Abcam,AB122897

What is this antibody validated in? Anti-ATF6 antibody [1-7] (ab122897) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of ATF6? Anti-ATF6 [1-7] (ab122897) specifically detects a band for ATF6 (UniProt: P18850) at a molecular weight of 75kDa. Trusted by the scientific community Anti-ATF6 [1-7] (ab122897) was first used in a scientific publication in 2011 and has been cited over 70 times in peer-reviewed journals. Reviewed by scientists Anti-ATF6 [1-7] (ab122897) has over 10 independent reviews from customers. Specificity confirmed The specificity of Anti-ATF6 antibody [1-7] (ab122897) has been confirmed by Immunocytochemistry testing in ATF6 Knockout HAP1 cells.

Host

Mouse

Reactivity

Human

Application

ICC/IF, WB, IP

Platform ID

BAB655208551

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-ATF6 antibody [1-7]
Cat. No.AB122897
HostMouse
IsotypeIgG2a
ReactivityHuman
ApplicationICC/IF, WB, IP
ClonalityMonoclonal
Clone Number1-7
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human ATF6. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 6 - 8.5 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cyclic AMP-dependent transcription factor ATF-6 alpha. Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed : 10564271, PubMed : 11158310, PubMed : 11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed : 10564271, PubMed : 11158310, PubMed : 11779464).. Processed cyclic AMP-dependent transcription factor ATF-6 alpha. Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed : 10564271, PubMed : 11158310, PubMed : 11163209, PubMed : 11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed : 10564271, PubMed : 11158310, PubMed : 11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed : 10564271, PubMed : 11158310, PubMed : 11779464). May play a role in foveal development and cone function in the retina (PubMed : 26029869). See full target information ATF6

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