Anti-ATG2A antibody,Abcam,AB226931

Host

Rabbit

Reactivity

Human

Application

WB, IP

Platform ID

BAB280420949

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-ATG2A antibody
Cat. No.AB226931
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, IP
ClonalityPolyclonal
Concentration2.36 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human ATG2A. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Lipid transfer protein involved in autophagosome assembly (PubMed : 28561066, PubMed : 30952800, PubMed : 31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed : 30952800, PubMed : 31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed : 30952800, PubMed : 31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed : 31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed : 22219374, PubMed : 28561066). See full target information ATG2A

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