Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y],Abcam,AB51253
Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Dot blot, ELISA, IHC-FrFl, IHC-P, WB in human, mouse, rat samples. Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253) has been cited over 373 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Alpha-synuclein (phospho S129) antibody (Anti-pS129 alpha synuclin antibody/ Anti-SNCA antibody) [EP1536Y] (ab51253) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253) has 9 independent reviews from customers. Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253) specifically detects Alpha-synuclein Phospho-S129 (UniProt ID: P37840; Molecular weight: 14kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EP1536Y - ab209422 . Antibody clone EP1536Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 750, PE, Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 594, Alexa Fluor® 568 ( ab321645 , ab314419 , ab225294 , ab225295 , ab311788 , ab313069 ). Alpha-synuclein phosphorylated at serine 129 (pS129; phosphorylated alpha synuclein, SNCA/NACP) is a modified form of the alpha-synuclein protein, which plays a crucial role in the regulation of synaptic vesicle trafficking and neurotransmitter release. This phosphorylation is significantly increased in the brains of patients with Parkinson's disease and other synucleinopathies. The presence of pS129 is associated with the formation of Lewy bodies, a hallmark of Parkinson's disease, and is believed to contribute to the neurotoxic properties of alpha-synuclein, exacerbating disease progression. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human, Mouse, Rat
Application
WB, IHC-FrFl, IHC-P, ELISA, Dot
Platform ID
BAB450972838
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed : 20798282, PubMed : 26442590, PubMed : 28288128, PubMed : 30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed : 28288128, PubMed : 30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed : 30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed : 20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed : 20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed : 26442590). See full target information SNCA phospho S129
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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