Anti-Ancient ubiquitous protein 1 antibody,Abcam,AB101984

Target data Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed : 18711132, PubMed : 21857022). Plays a role in lipid droplet formation (PubMed : 21857022). Induces lipid droplet clustering (PubMed : 24039768). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed : 21127063, PubMed : 23223569). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed : 23223569). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed : 28183703).. (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles. See full target information AUP1