Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade,Abcam,AB108341
Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ChIC/CUT&RUN-seq, ChIP, ICC/IF, IHC-P, WB in human, mouse, rat samples. Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) has been cited over 79 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) has 4 independent reviews from customers. Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) specifically detects Androgen Receptor (UniProt ID: P10275; Molecular weight: 99kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone ER179(2) - ab212175 . Antibody clone ER179(2) is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 594 ( ab22352 , ab22432 , ab2269 , ab26358). The androgen receptor (AR)/DHTR plays a crucial role in the development and progression of various cancers, including breast cancer and prostate cancer. Utilizing our highly-validated AR antibody, can significantly enhance the detection and study of AR expression. Research indicates that AR is a promising therapeutic target for treating hormone-dependent cancers, offering potential for improved patient outcomes. Validated also for CUT&RUN, which is a key applications to map protein-DNA interactions on a genome-wide scale using NGS. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ICC/IF, WB, ChIP, ChIC/CUT&RUN-seq, IHC-P
Platform ID
BAB640015847
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The protein expressed by the AR gene functions as a steroid hormone receptor, a type of ligand-activated transcription factor that regulates eukaryotic gene expression and influences cellular proliferation and differentiation in target tissues. Its transcription factor activity can be modulated by coactivator and corepressor proteins, such as ZBTB7A, which recruits NCOR1 and NCOR2 to androgen response elements on target genes, thereby negatively regulating androgen receptor signaling and androgen-induced cell proliferation. The transcription activation can also be down-regulated by NR0B2. The protein is activated, though not phosphorylated, by HIPK3 and ZIPK/DAPK3. Notably, isoforms 3 and 4 of this protein lack the C-terminal ligand-binding domain and may thus constitutively activate transcription of specific gene sets independently of steroid hormones. This supplementary information is collated from multiple sources and compiled automatically. See full target information AR
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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