Anti-Aprataxin antibody [S03-9F6],Abcam,AB317382

Target data DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed : 15044383, PubMed : 15380105, PubMed : 16964241, PubMed : 17276982, PubMed : 24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed : 16964241, PubMed : 24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed : 16964241, PubMed : 17276982, PubMed : 24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed : 16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). See full target information APTX