Anti-Aquaporin 4 antibody [4/18],Abcam,AB9512

What is this antibody validated in? Anti-Aquaporin 4 antibody [4/18] (ab9512) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), ELISA in Human, Mouse, Rabbit, Rat, Zebrafish samples. Trusted by the scientific community Anti-Aquaporin 4 [4/18] (ab9512) was first used in a scientific publication in 2002 and has been cited over 40 times in peer-reviewed journals. Reviewed by scientists Anti-Aquaporin 4 [4/18] (ab9512) has over 5 independent reviews from customers.

Host

Mouse

Reactivity

Rat, Zebrafish, Mouse, Rabbit, Human

Application

ELISA, IHC-FoFr, IHC-P, IHC-Fr

Platform ID

BAB902035075

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Aquaporin 4 antibody [4/18]
Cat. No.AB9512
HostMouse
IsotypeIgG3
ReactivityRat, Zebrafish, Mouse, Rabbit, Human
ApplicationELISA, IHC-FoFr, IHC-P, IHC-Fr
ClonalityMonoclonal
Clone Number4/18
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Rat Aqp4 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.097% Sodium azide Constituents: PBS, 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Forms a water-specific channel (PubMed : 19383790, PubMed : 7559426, PubMed : 8601457). Plays an important role in brain water homeostasis (PubMed : 37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). See full target information AQP4

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