Anti-Artemis antibody [HL1227] - BSA and Azide free,Abcam,AB313837
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Host
Rabbit
Reactivity
Human
Application
ICC/IF, WB
Platform ID
BAB028696777
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed : 11336668, PubMed : 11955432, PubMed : 12055248, PubMed : 14744996, PubMed : 15071507, PubMed : 15574326, PubMed : 15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed : 11336668, PubMed : 11955432, PubMed : 14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed : 11336668, PubMed : 11955432, PubMed : 14744996). These DSBs present two types of DNA end structures : hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed : 11336668, PubMed : 11955432, PubMed : 14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed : 11336668, PubMed : 11955432, PubMed : 14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed : 11955432, PubMed : 15071507, PubMed : 15574326, PubMed : 15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed : 11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed : 15456891, PubMed : 15468306, PubMed : 15574327, PubMed : 15811628). See full target information DCLRE1C
Category Paths
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