Anti-BACE1 antibody [EPR19523],Abcam,AB183612

What is this antibody validated in? Anti-BACE1 antibody [EPR19523] (ab183612) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Human, Mouse, Rat samples. What is the molecular weight of BACE1? Anti-BACE1 [EPR19523] (ab183612) specifically detects a band for BACE1 (UniProt: P56818) at a molecular weight of 56kDa. Trusted by the scientific community Anti-BACE1 [EPR19523] (ab183612) was first used in a scientific publication in 2016 and has been cited over 30 times in peer-reviewed journals. Reviewed by scientists Anti-BACE1 [EPR19523] (ab183612) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-BACE1 antibody [EPR19523] (ab183612) has been confirmed by Western blot testing in BACE1 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR19523] also available for your convenience: ab183612, Carrier free - ab238937 , Alexa Fluor® 647 - ab225307 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

IP, IHC-Fr, IHC-P, WB

Platform ID

BAB345700864

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-BACE1 antibody [EPR19523]
Cat. No.AB183612
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationIP, IHC-Fr, IHC-P, WB
ClonalityMonoclonal
Clone NumberEPR19523
Concentration0.707 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed : 10656250, PubMed : 10677483, PubMed : 20354142). Cleaves CHL1 (By similarity). See full target information BACE1

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