Anti-BACH1/BRIP1 antibody - N-terminal,Abcam,AB151509

Target data DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed : 11301010, PubMed : 14983014, PubMed : 16116421, PubMed : 16153896, PubMed : 17596542, PubMed : 36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed : 14983014, PubMed : 16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed : 14983014, PubMed : 16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links : acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed : 16116421, PubMed : 36608669). Can unwind RNA : DNA substrates (PubMed : 14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed : 18426915, PubMed : 20639400). See full target information BRIP1