Anti-BAP1 antibody [EPR22826-65],Abcam,AB255611
What is this antibody validated in? Anti-BAP1 antibody [EPR22826-65] (ab255611) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples. What is the molecular weight of BAP1? Anti-BAP1 [EPR22826-65] (ab255611) specifically detects a band for BAP1 (UniProt: Q92560) at a molecular weight of 80kDa. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR22826-65] also available for your convenience: ab255611, Carrier free - ab256480 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Rat, Mouse, Human
Application
Flow Cyt (Intra), WB, IHC-P
Platform ID
BAB971612926
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed : 12485996, PubMed : 18757409, PubMed : 20436459, PubMed : 25451922, PubMed : 35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed : 20436459, PubMed : 25451922, PubMed : 30664650, PubMed : 35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed : 20436459, PubMed : 30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed : 20805357, PubMed : 30664650, PubMed : 36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed : 30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed : 36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed : 20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed : 19188440, PubMed : 19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed : 19188440, PubMed : 19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed : 19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed : 19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed : 24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed : 34170818). See full target information BAP1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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