Anti-BRAF (mutated V600E) antibody [VE1],Abcam,AB228461

Anti-BRAF (mutated V600E) antibody [VE1] (ab228461) is a mouse recombinant monoclonal antibody and is validated for use in IHC-P and WB. Anti-BRAF (mutated V600E) antibody [VE1] (ab228461) was first used in a scientific publication in 2011 and has been cited over 116 times in peer reviewed journals. It's performance in IHC in human and mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-BRAF (mutated V600E) antibody [VE1] (ab228461) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-BRAF (mutated V600E) antibody [VE1] (ab228461) has 6 independent reviews from customers. Anti-BRAF (mutated V600E) antibody [VE1] (ab228461) specifically detects BRAF Mutated-V600E (UniProt ID: P15056; Molecular weight: 85kDa) and is sold in 100 µL, 500 µL and 1 mL selling sizes. The BRAF gene helps control cell growth, mutations in BRAF can lead to uncontrolled cell division contributing to cancer. These mutations are common in cancers like melanoma, colon and thyroid, targeted therapies have been developed to treat cancers with BRAF mutations. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Human

Application

WB, IHC-P

Platform ID

BAB606520668

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-BRAF (mutated V600E) antibody [VE1]
Cat. No.AB228461
HostMouse
IsotypeIgG2b
ReactivityHuman
ApplicationWB, IHC-P
ClonalityMonoclonal
Clone NumberVE1
Concentration0.72 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.5 Preservative: 0.1% Sodium azide Constituents: Tris, 0.3% Carrier protein
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed : 21441910, PubMed : 29433126). Phosphorylates PFKFB2 (PubMed : 36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed : 1508179). See full target information BRAF mutated V600E

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