Anti-BSCL2/Seipin antibody,Abcam,AB181761

Target data Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed : 19278620, PubMed : 21533227, PubMed : 30293840, PubMed : 31708432). In association with LDAF1, defines the sites of LD formation in the ER (PubMed : 31708432). Also required for growth and maturation of small nascent LDs into larger mature LDs (PubMed : 27564575). Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (PubMed : 27879284, PubMed : 31178403). Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (PubMed : 30970241). Binds anionic phospholipids including phosphatidic acid (PubMed : 30293840). Plays an important role in the differentiation and development of adipocytes (By similarity). See full target information Seipin