Anti-Bcl-2 antibody,Abcam,AB194583
What is this antibody validated in? Anti-Bcl-2 antibody (ab194583) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of Bcl-2? Anti-Bcl-2 (ab194583) specifically detects a band for Bcl-2 (UniProt: P10415) at a molecular weight of 26kDa. Trusted by the scientific community Anti-Bcl-2 (ab194583) was first used in a scientific publication in 2014 and has been cited over 140 times in peer-reviewed journals.
Host
Rabbit
Reactivity
Mouse, Human, Rat
Application
ICC/IF, IP, WB, IHC-P
Platform ID
BAB097475012
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed : 1508712, PubMed : 8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed : 11368354). Appears to function in a feedback loop system with caspases (PubMed : 11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed : 11368354). Also acts as an inhibitor of autophagy : interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed : 18570871, PubMed : 20889974, PubMed : 21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed : 17418785). See full target information BCL2
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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