Anti-Blooms Syndrome Protein Blm antibody,Abcam,AB5446

Target data ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed : 24816114, PubMed : 25901030, PubMed : 9388193, PubMed : 9765292). Participates in DNA replication and repair (PubMed : 12019152, PubMed : 21325134, PubMed : 23509288, PubMed : 34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair : unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed : 21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed : 25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed : 20639533, PubMed : 24257077, PubMed : 25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed : 18426915, PubMed : 9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed : 9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed : 18426915, PubMed : 9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed : 25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity).. (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. See full target information BLM