Anti-C3Orf34 antibody,Abcam,AB221816

Host

Rabbit

Reactivity

Human

Application

ICC/IF

Platform ID

BAB860543736

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-C3Orf34 antibody
Cat. No.AB221816
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF
ClonalityPolyclonal
Concentration0.4 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human CEP19 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Required for ciliation (PubMed : 28428259, PubMed : 28625565, PubMed : 28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed : 28428259, PubMed : 28625565). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (PubMed : 28659385). See full target information CEP19

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