Anti-C5a-R antibody [P12/1],Abcam,AB24036

Host

Mouse

Reactivity

Human, Rhesus monkey

Application

Flow Cyt, WB, IHC-P, IHC-Fr

Platform ID

BAB735981026

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-C5a-R antibody [P12/1]
Cat. No.AB24036
HostMouse
IsotypeIgG2a
ReactivityHuman, Rhesus monkey
ApplicationFlow Cyt, WB, IHC-P, IHC-Fr
ClonalityMonoclonal
Clone NumberP12/1
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human C5AR1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.09% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed : 10636859, PubMed : 15153520, PubMed : 1847994, PubMed : 29300009, PubMed : 7622471, PubMed : 8182049, PubMed : 9553099). The ligand interacts with at least two sites on the receptor : a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed : 7622471, PubMed : 8182049, PubMed : 9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed : 10636859, PubMed : 15153520). See full target information C5AR1

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