Anti-CBS antibody,Abcam,AB96252

Host

Rabbit

Reactivity

Human, Zebrafish

Application

IHC-P, WB, ICC/IF, IP

Platform ID

BAB617315484

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CBS antibody
Cat. No.AB96252
HostRabbit
IsotypeIgG
ReactivityHuman, Zebrafish
ApplicationIHC-P, WB, ICC/IF, IP
ClonalityPolyclonal
Concentration0.18 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human CBS aa 1-250. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed : 20506325, PubMed : 23974653, PubMed : 23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). See full target information CBS

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