Anti-CCDC134 antibody,Abcam,AB106442

Target data In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed : 25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed : 25125657). May inhibit ERK and JNK signaling activity (PubMed : 18087676, PubMed : 23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed : 23070808). Has a critical role in the regulation of osteogenesis and bone development (PubMed : 32181939).. In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. See full target information Coiled-coil domain-containing protein 134