Anti-CCR1 antibody [HL2840] - BSA and Azide free,Abcam,AB325842

Target data Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed : 14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed : 15905581, PubMed : 38417634). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4 (By similarity). Also mediates monocyte migration upon CXCL4 binding (PubMed : 29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity). See full target information CCR1