Anti-CCR2 antibody [EPR20844-15],Abcam,AB273050
Anti-CCR2 antibody [EPR20844-15] (ab273050) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt, ICC/IF, IHC-P, IP, WB in mouse, rat samples. Anti-CCR2 antibody [EPR20844-15] (ab273050) has been cited over 17 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-CCR2 antibody [EPR20844-15] (ab273050) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-CCR2 antibody [EPR20844-15] (ab273050) has been confirmed by testing in knockout samples. Anti-CCR2 antibody [EPR20844-15] (ab273050) specifically detects CCR2 (UniProt ID: P51683; Molecular weight: 43kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR20844-15 - ab273061 . Antibody clone EPR20844-15 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 594, APC ( ab302579 , ab302666 , ab303469 , ab314258 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat
Application
Flow Cyt, ICC/IF, WB, IHC-P, IP
Platform ID
BAB618514908
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Key functional receptor for CCL2 but can also bind CCL7 and CCL12 chemokines (PubMed : 8631787, PubMed : 8662823, PubMed : 8996246). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (PubMed : 28507030). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (PubMed : 29930553). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed : 29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed : 29993042). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (PubMed : 24806994, PubMed : 29632244). See full target information Ccr2
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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