Anti-CD11b antibody [EPR1344],Abcam,AB133357
Anti-CD11b antibody [EPR1344] (ab133357) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P, WB and mIHC. Anti-CD11b antibody [EPR1344] (ab133357) was first used in a scientific publication in 1976 and has been cited over 347 times in peer reviewed journals. It's performance in IHC in mouse and human samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-CD11b antibody [EPR1344] (ab133357) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD11b antibody [EPR1344] (ab133357) has 31 independent reviews from customers. Anti-CD11b antibody [EPR1344] (ab133357) specifically detects CD11b (UniProt ID: P11215; Molecular weight: 126kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR1344 - ab209970 . Antibody clone EPR1344 is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor ® 488, Alexa Fluor ® 555, Alexa Fluor ® 647, Alexa Fluor ® 594, Alexa Fluor ® 568, Alexa Fluor ® 750, Biotin ( ab204472 , ab307387 , ab307391 , ab307523 , ab311811 , ab313094 , ab321047 , ab322298 ). CD11b is involved in various diseases by regulating immune cell adhesion, migration and activation, which can influence inflammation, autoimmune conditions and cancer progression. Multiplex IHC staining using Opal in mouse spleen tissue Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, IHC-P, mIHC
Platform ID
BAB869639368
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed : 20008295, PubMed : 9558116). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed : 28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed : 21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). See full target information ITGAM
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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