Anti-CD11b antibody [M1/70],Abcam,AB8878
Anti-CD11b antibody [M1/70] (ab8878) is a rat recombinant monoclonal antibody and is validated for use in Flow Cyt, ICC/IF in mouse, rat samples. Anti-CD11b antibody [M1/70] (ab8878) has been cited over 158 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-CD11b antibody [M1/70] (ab8878) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD11b antibody [M1/70] (ab8878) has 14 independent reviews from customers. Anti-CD11b antibody [M1/70] (ab8878) specifically detects CD11b (UniProt ID: P05555; Molecular weight: 126kDa) and is sold in a convenient trial size to enable initial testing (20 µg) and larger sizes for subsequent scaling up experiments (100 µg and 1 mg). Conjugation-ready, carrier free format available for antibody clone M1/70 - ab237965 . Antibody clone M1/70 is also available pre-conjugated to a variety of labels for your convenience - FITC, PE, APC, PE/Cy5®, APC/Cy7®, Alexa Fluor® 488, Alexa Fluor® 647, PerCP/Cy5.5® ( ab24874 , ab25175 , ab25482 , ab25533 , ab79096 , ab197701 , ab197702 , ab210299 ). Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected] What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rat
Reactivity
Mouse, Human
Application
Flow Cyt, ICC/IF
Platform ID
BAB994701838
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed : 20008295, PubMed : 9558116). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen and factor X. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed : 28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed : 21193407). Integrin ITGAM/ITGB2 is also a receptor for ICAM1 ligand ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed : 1980124). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). See full target information ITGAM
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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