Anti-CD133 antibody [293C3],Abcam,AB252553

Host

Mouse

Reactivity

Human

Application

Flow Cyt

Platform ID

BAB245226586

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CD133 antibody [293C3]
Cat. No.AB252553
HostMouse
IsotypeIgG2b
ReactivityHuman
ApplicationFlow Cyt
ClonalityMonoclonal
Clone Number293C3
Concentration1 mg/mL Batch dependent concentration
ImmunogenFull Length Protein corresponding to Human PROM1. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data May play a role in cell differentiation, proliferation and apoptosis (PubMed : 24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed : 20818439). See full target information PROM1

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