Anti-CD161 antibody [B199.2],Abcam,AB23624

Myeloma cell line: P2X63.Ag8.653

Host

Mouse

Reactivity

Human

Application

IP, Flow Cyt, IHC-Fr

Platform ID

BAB808857293

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CD161 antibody [B199.2]
Cat. No.AB23624
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationIP, Flow Cyt, IHC-Fr
ClonalityMonoclonal
Clone NumberB199.2
Concentration1 mg/mL Batch dependent concentration
ImmunogenCell preparation containing KLRB1 protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. See full target information KLRB1

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