Anti-CD161 antibody [OTI1D8] - BSA and Azide free,Abcam,AB273666

Host

Mouse

Reactivity

Human

Application

IHC-P, WB

Platform ID

BAB683894775

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CD161 antibody [OTI1D8] - BSA and Azide free
Cat. No.AB273666
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationIHC-P, WB
ClonalityMonoclonal
Clone NumberOTI1D8
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human KLRB1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A/G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. See full target information KLRB1

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