Anti-CD163 antibody [EPR19518],Abcam,AB182422
Anti-CD163 antibody [EPR19518] (ab182422) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt, IHC-Fr IHC-P, WB and mIHC. Anti-CD163 antibody [EPR19518] (ab182422) was first used in a scientific publication in 2014 and has been cited over 399 times in peer reviewed journals. It's performance in IHC in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-CD163 antibody [EPR19518] (ab182422) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD163 antibody [EPR19518] (ab182422) has 17 independent reviews from customers. Anti-CD163 antibody [EPR19518] (ab182422) specifically detects CD163 (UniProt ID: Q2VLH6; Molecular weight: 118kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR19518 - ab213612 . Antibody clone EPR19518 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 555, Alexa Fluor ® 594, Alexa Fluor ® 488, Alexa Fluor ® 647, Biotin, PE ( ab281746 , ab282114 , ab313665 , ab313666 , ab314941 , ab314947 ). Recombinant antibody to CD163 is involved in conditions like rheumatoid arthritis and atherosclerosis, where it helps regulate inflammation. Top cited clone on the market Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
mIHC, IHC-P, IHC-Fr, WB, Flow Cyt
Platform ID
BAB121463492
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. See full target information CD163
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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