Anti-CD21 antibody [SP186] - C-terminal,Abcam,AB227662
What is this antibody validated in? Anti-CD21 antibody [SP186] - C-terminal (ab227662) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Human, Mouse, Rat samples. What is the molecular weight of CD21? Anti-CD21 [SP186] - C-terminal (ab227662) specifically detects a band for CD21 (UniProt: P20023) at a molecular weight of 113kDa. Collaboration Anti-CD21 [SP186] - C-terminal (ab227662) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC). Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [SP186] also available for your convenience: ab227662, Carrier free - ab240987 , ab279465, PE - ab306325 , APC - ab306326 , HRP - ab306327 , Alkaline Phosphatase - ab308986 , Alexa Fluor® 488 - ab309929 , Alexa Fluor® 647 - ab310296 , Alexa Fluor® 594 - ab310758 , Alexa Fluor® 555 - ab312285 , Alexa Fluor® 568 - ab312780 , Alexa Fluor® 750 - ab321441
Host
Rabbit
Reactivity
Rat, Human, Mouse, Cat, Dog, Horse, Pig, Llama
Application
IHC-Fr, WB, Flow Cyt (Intra), IHC-P
Platform ID
BAB560631441
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1 (PubMed : 1849076, PubMed : 21527715, PubMed : 7753047). When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells (PubMed : 21527715). This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling (PubMed : 1383329, PubMed : 30107486). Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner (PubMed : 12938232). Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production (PubMed : 1386409).. (Microbial infection) Acts as a receptor for Epstein-Barr virus. See full target information CR2
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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