Anti-CD276 antibody [BLR025F] - BSA free,Abcam,AB243882

REACH authorisation Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances. It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses. This product is sold under License from Bethyl Laboratories, Inc.

Host

Rabbit

Reactivity

Human, Mouse

Application

IHC-P, Flow Cyt, ICC, WB, IP

Platform ID

BAB249024762

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-CD276 antibody [BLR025F] - BSA free
Cat. No.AB243882
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse
ApplicationIHC-P, Flow Cyt, ICC, WB, IP
ClonalityMonoclonal
Clone NumberBLR025F
ImmunogenSynthetic Peptide within Human CD276 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.8 - 8.6 Preservative: 0.09% Sodium azide Constituents: 99% Borate buffered saline
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. See full target information CD276

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