Anti-CD3 epsilon antibody,Abcam,AB5690
Product Specifications Anti-CD3 epsilon antibody (ab5690) is a rabbit polyclonal antibody and is validated for use in IHC-P, WB in human, mouse, rat samples. Anti-CD3 epsilon antibody (ab5690) specifically detects CD3 epsilon (UniProt ID: P07766; Molecular weight: 21kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-CD3 epsilon antibody (ab5690) has high sensitivity and specificity. Anti-CD3 epsilon antibody (ab5690) has been cited over 548 times in peer reviewed journals and is trusted by the scientific community. Anti-CD3 epsilon antibody (ab5690) has 46 independent reviews from customers. Target Information CD3 epsilon (CD3ε) is a protein subunit of the CD3 complex, which is essential for T-cell receptor (TCR) signaling and T-cell activation. It plays a crucial role in the immune response by facilitating the recognition of antigens. CD3ε is widely used as a marker for T cells in immunological studies. Mutations or defects in CD3ε can lead to severe combined immunodeficiency (SCID), characterized by the absence of functional T cells, resulting in increased susceptibility to infections and impaired immune responses.
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, WB
Platform ID
BAB749374594
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed : 2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed : 10384095, PubMed : 26507128). In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1. Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx (PubMed : 38614099). See full target information CD3E
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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