Anti-CD31 antibody [JC/70A],Abcam,AB9498

Anti-CD31 antibody [JC/70A] (ab9498) is a mouse monoclonal antibody and is validated for use in Flow Cyt, ICC/IF, IHC-Fr, IHC-P and WB. Abcam's high quality validation processes ensure Anti-CD31 antibody [JC/70A] (ab9498) has high sensitivity and specificity. Anti-CD31 antibody [JC/70A] (ab9498) has 38 independent reviews from customers. Anti-CD31 antibody [JC/70A] (ab9498) specifically detects CD31 (UniProt ID: P16284; Molecular weight: 80kDa) and is sold in 100 ug selling sizes. Conjugation-ready, carrier free format available for antibody clone JC/70A - ab264090 . Antibody clone JC/70A is also available pre-conjugated to a variety of labels for your convenience - PE, Alexa Fluor ® 488, Alexa Fluor ® 647 ( ab21566 , ab215911 , ab215912 ). CD31 (PECAM-1) is a protein expressed on endothelial and immune cells, playing a crucial role in tumor angiogenesis and immune cell trafficking. In immuno-oncology, it influences the tumor microenvironment and modulates the immune response to cancer Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Human

Application

IHC-P, WB, ICC/IF, IHC-Fr, Flow Cyt

Platform ID

BAB562630481

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CD31 antibody [JC/70A]
Cat. No.AB9498
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationIHC-P, WB, ICC/IF, IHC-Fr, Flow Cyt
ClonalityMonoclonal
Clone NumberJC/70A
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.02% Sodium azide Constituents: PBS, 6.97% L-Arginine
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed : 17580308, PubMed : 19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed : 19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed : 27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed : 17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed : 12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed : 12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed : 18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed : 18672896). Induces susceptibility to atherosclerosis (By similarity).. Isoform Delta15. Does not protect against apoptosis. See full target information PECAM1

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