Anti-CD31 antibody [MEC 7.46],Abcam,AB7388
What is this antibody validated in? Anti-CD31 antibody [MEC 7.46] (ab7388) is a rat recombinant monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples. Trusted by the scientific community Anti-CD31 [MEC 7.46] (ab7388) was first used in a scientific publication in 2002 and has been cited over 130 times in peer-reviewed journals. Reviewed by scientists Anti-CD31 [MEC 7.46] (ab7388) has over 5 independent reviews from customers. Other related products We have a range of other formats of antibody clone [MEC 7.46] also available for your convenience: ab7388, Carrier free - ab264486 , Alexa Fluor® 488 - ab307133 , Alexa Fluor® 647 - ab307262 , Alexa Fluor® 594 - ab307336 , PE - ab314282 What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rat
Reactivity
Mouse
Application
ICC/IF, Flow Cyt
Platform ID
BAB125161716
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity). Modulates bradykinin receptor BDKRB2 activation (By similarity). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity). Induces susceptibility to atherosclerosis (PubMed : 19048083). See full target information Pecam1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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