Anti-CD31 antibody [P2B1],Abcam,AB24590
Anti-CD31 antibody [P2B1] (ab24590) is a mouse monoclonal antibody and is validated for use in ICC, IHC-Fr, WB in human samples. Anti-CD31 antibody [P2B1] (ab24590) has been cited over 291 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-CD31 antibody [P2B1] (ab24590) has high sensitivity and specificity. Anti-CD31 antibody [P2B1] (ab24590) has 32 independent reviews from customers. Anti-CD31 antibody [P2B1] (ab24590) specifically detects CD31 (UniProt ID: P16284; Molecular weight: 80kDa) and is sold in 100 µg selling sizes. ab24590 activates the binding of human T-lymphocytes to endothelial cells. Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]
Host
Mouse
Reactivity
Human
Application
IHC-Fr, ICC, WB
Platform ID
BAB750174210
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed : 17580308, PubMed : 19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed : 19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed : 27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed : 17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed : 12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed : 12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed : 18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed : 18672896). Induces susceptibility to atherosclerosis (By similarity).. Isoform Delta15. Does not protect against apoptosis. See full target information PECAM1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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