Anti-CD41 antibody [7E3 (Abciximab)] - Rabbit IgG (Chimeric),Abcam,AB275976

This rabbit monoclonal chimeric antibody was made using the variable domain sequences of the original human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Host

Rabbit

Reactivity

Human

Application

Flow Cyt

Platform ID

BAB939317171

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CD41 antibody [7E3 (Abciximab)] - Rabbit IgG (Chimeric)
Cat. No.AB275976
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationFlow Cyt
ClonalityMonoclonal
Clone Number7E3 (Abciximab)
Concentration0.5 - 1 mg/mL Batch dependent concentration
ImmunogenCell preparation containing ITGA2B protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.02% Proclin 300 Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed : 9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). See full target information ITGA2B

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